Our Team
Dedicated professionals pushing the boundaries of neurobiology.
Principal Investigator
김양희 Yang-Hee Kim, Ph.D.
바이오융합공학과 교수Education
- Ph.D. in Neuroscience, Seoul National University, Korea (1997~2000)
- M.S. in Cell Biology, Seoul National University, Korea (1993~1995)
- B.S. in Biology, Yonsei University, Korea (1988~1992)
Research and Professional Experience
- 2020~present: Founder and CTO, Zincure Corp. (Faculty Startup)
- 2016~Present: Professor in Dept. of Integrative Bioscience and Biotechnology, Sejong University
- 2008~2015: Associate Professor in Dept. of Molecular Biology, Sejong University
- 2009~2010: Visiting Professor in Sanford-Burnham Medical Research Institute, La Jolla, CA, USA
- 2004~2008: Assistant Professor in Dept. of Molecular Biology, Sejong University
- 2002~2004: Instructor in Dept. of Molecular Biology, Sejong University
- 2000~2002: Postdoctoral Researcher, National Creative Research Initiative Center for the Study of CNS Zinc, University of Ulsan College of Medicine, Seoul, Korea
Zincure Researcher
이진연 Jin Yeon Lee Ph.D
Education
- Ph.D. in Molecular Biology, Sejong University, Korea (2024-2026)
- M.S. in Molecular Biology, Sejong University, Korea (2004-2006)
Research Experience
- Principal Researcher, Research and Development Institute / BioSolution. o., Ltd. (2021-2022)
- Senior Researcher, Research and Development Institute / BioSolution. Co., Ltd. (2006-2019)
Research Interests / Current Projects
- Investigation of the role of zinc and lysosome in acute brain injury
- Elucidation of the zinc- and lysosome-dependent neuroprotective effects of Trehalose in ischemic brain injury
- Development of a novel MMP-9 inhibitor that prevents BBB breakdown in a pMCAO rat model
Publications
- Jae-Won Eom, Jin-Yeon Lee, Yeabin Kwon and Yang-Hee Kim, An increase of lysosomes through EGF-triggered endocytosis attenuated zinc-mediated lysosomal membrane permeabilization and neuronal cell death, Cell Death and Disease, 2024.
- Jin-Yeon Lee, Yu-Jin Kim, Tae-Youn Kim, Jae-Young Koh and Yang-Hee Kim. (2008). Essential Role for Zinc-Triggered p75NTR Activation in Preconditioning Neuroprotection. The Journal of Neuroscience, 2008.
Patents
- New compounds and their uses. KR/20240080461 (Filling Date: Jun 20, 2024)
- Artificial cartilage containing chondrocytes obtained from costal cartilage and preparation process thereof. KR/10-0917422 (Registered: 2009.09.16)
- Preparation Method for therapeutic agent of bead-type chondrocyte. KR/10-1814440 (Registered: 2017.12.27)
김기령 Ki-Ryeong Kim, Ph.D.
Education
- Ph.D. in Integrative Bioscience and Biotechnology, Sejong University, Korea (2013~2019)
- B.S. in Molecular biology, Sejong University, Korea (2006~2012)
Research Experience
- Postdoctoral researcher in Integrative Bioscience and Biotechnology, Sejong University (2020~2021)
Research Interests / Current Projects
- Development of therapeutics for neurodegenerative diseases
- Zinc-mediated lysosomal activation mechanisms
Publications
- Zinc enhances autophagic flux and lysosomal function through transcription factor EB activation and V-ATPase assembly. Front Cell Neurosci. 2022.
- S-Nitrosylation of cathepsin B affects autophagic flux and accumulation of protein aggregates in neurodegenerative disorders. Cell Death Differ. 2022.
- Zinc preconditioning protects against neuronal apoptosis through the mitogen-activated protein kinase-mediated induction of heat shock protein 70. Biochem Biophys Res Commun. 2015.
- Poly(ADP-ribosyl)ation of p53 contributes to TPEN-induced neuronal apoptosis. Mol Cells. 2015.
Patents
- Novel peptide and use thereof. KR20250009999A, WO2023229442A1, JP2025517813A, CN119403821A, EP4534546A1 (Filling Date: May 26, 2023)
- Novel peptide and use thereof. KR20250010000A, WO2023229445A1, JP2025519164A, CN119403819A, EP4534545A1 (Filling Date: May 26, 2023)
김동혁 Dong-hyuk Kim. M.S.
Education
- EM.S. in Neuroscience, Sejong University, Korea (2022~2024)
- B.S. in Integrative Bioscience and Biotechnology, Sejong University, Korea (2016~2022)
Research Interests / Current Projects
- Development of Stroke therapeutics
- Investigation of MMP-9-mediated neuroinflammatory mechanisms
- Exploration of the therapeutic potential of MMP-9 inhibitor in CNS disorders
Patents
- New compounds and their uses. KR/20240080461 (Filling Date: Jun 20, 2024)
권예빈 Yeabin Kwon
Education
- M.S. in Integrative Bioscience and Biotechnology, Sejong University, Korea (2025~2026)
- B.S. in Integrative Bioscience and Biotechnology, Sejong University, Korea (2019~2024)
Research Interests / Current Projects
- Investigation of MMP-9-mediated neuronal death mechanisms in ischemic brain injury
- Development of novel MMP-9 inhibitor and exploration of therapeutic strategies for stroke
Publications
- Jae-Won Eom, Jin-Yeon Lee, Yeabin Kwon and Yang-Hee Kim An increase of lysosomes through EGF-triggered endocytosis attenuated zinc-mediated lysosomal membrane permeabilization and neuronal cell death, cell death & disease, 2024.
Graduate Student
최한샘 Han-Saem Choi
석박통합과정Education
- B.S. in Integrative Bioscience and Biotechnology, Sejong University, Korea (2017~2021)
Research Interests / Current Projects
- Investigation of zinc’s essential role in progranulin-mediated lysosomal activation
- Elucidation of the protective effects of the lysosomal activator ZCS1 in progranulin-deficient transgenic mice
Publications
- Na DK, Lim DH, Hong JS, Lee HM, Cho DA, Yu MS, Shaker B, Ren J, Lee BM, Song JG, Oh YN, Lee KE, Oh KS, Lee MY, Choi MS, Choi HS, Kim YH, Bui JM, Lee KS, Kim HW, Lee YS, Gsponer J A multi-layered network model identifies Akt1 as a common modulator of neurodegeneration. (2023) Molecular Systems Biology 19: e11801.
이현승 Hyun Seung Lee
박사과정Education
- M.S. in Integrative Bioscience and Biotechnology, Sejong University in Korea (2020~2022)
- B.S. in Integrative Bioscience and Biotechnology, Sejong University in Korea (2015~2020)
Research Interests / Current Projects
- Development of therapeutics for ALS
- Investigation of zinc-centered pathogenic mechanism in ALS
- Research on the role of LMP in neurodegenerative diseases
Publications
- Zinc-mediated lysosomal distablization links mitochondrial damage to neuronal death in a cellular MPP+ model of Parkinson's Disease. J Neurochem. 2026.
Patents
- Novel peptide and use thereof. KR20250009999A, WO2023229442A1, JP2025517813A, CN119403821A, EP4534546A1 (Filling Date: May 26, 2023)
- Novel peptide and use thereof. KR20250010000A, WO2023229445A1, JP2025519164A, CN119403819A, EP4534545A1 (Filling Date: May 26, 2023)
김송희 Song-Hee Kim
학석사연계과정Education
- B.S. in Integrative Bioscience and Biotechnology, Sejong University, Korea (2022~2025)
Research Interests / Current Projects
- Investigation of pathogenic factors contributing to ALS onset and the development of potential therapeutics
- Elucidation of pathological mechanisms underlying BMAA-induced neurotoxicity
- Evaluation of the protective effects and underlying mechanisms of the lysosomal activator ZCS1 in a BMAA-induced ALS-PD animal model
전관호 Kwanho Jeon
학석사연계과정Education
- B.S. in Integrative Bioscience and Biotechnology, Sejong University, Korea (2019~2026)
Research Interests / Current Projects
- Investigation of the pathological mechanisms of ALS
- Elucidation of the mechanism by which reduced RCAN1 and TRPML1 expression impairs TFEB activation and lysosomal biogenesis during BMAA-induced neurotoxicity
Undergraduate
실험실에 지원할 학부생을 기다립니다~!!
Undergraduate ResearcherFocus
- 신경질환 연구와 신약개발에 열정을 가진 대학원생을 모집합니다
