Selected Publications
Our contributions to the global scientific community.
Zinc-mediated lysosomal distablization links mitochondrial damage to neuronal death in a cellular MPP+ model of Parkinson's Disease.
HS Lee, SA Kang, JW Eom, MS Kim, JS Kim, YH
Kim
Journal of Neurochemistry 17 (2): e70363
An increase of lysosomes through EGF-triggered endocytosis attenuated zinc-mediated lysosomal membrane permeabilization and neuronal cell death.
JW Eom, JY Lee, YB Kwon, YH Kim
Death &
Disease 15 (11): 823
S-Nitrosylation of cathepsin B affects autophagic flux and accumulation of protein aggregates in neurodegenerative disorders.
KR Kim, EJ Cho, JW Eom, SS Oh, T Nakamura, C
Oh, SA Lipton, YH Kim
Cell Death & Differentiation 29 (11), 2137-2150
Zinc enhances autophagic flux and lysosomal function through transcription factor EB activation and V-ATPase assembly.
Kim KR, Park SE, Hong JY, Koh JY, Cho DH,
Hwang JJ, Kim YH
Front Cell Neurosci
The inhibition of zinc excitotoxicity and AMPK phosphorylation by novel zinc chelator, 2G11, ameliorates neuronal death induced by global cerebral ischemia.
Hong DK, Eom JW, Kho AR, Lee SH, Kang BS, Lee
SH, Koh JY Kim YH, Suh SW,
Antioxidants 11 (11): 2192-2210.
Mechanism of zinc excitotoxicity: a focus on AMPK
YH Kim, JW Eom, JY Koh
Frontiers in
Neuroscience 14, 577958
A novel zinc chelator, 1H10, ameliorates experimental autoimmune encephalomyelitis by modulating zinc toxicity and AMPK activation
BY Choi, JH Jeong, JW Eom, JY Koh, YH Kim, SW
Suh
International Journal of Molecular Sciences 21 (9), 3375
Lysosomal dysfunction in proteinopathic neurodegenerative disorders: possible therapeutic roles of cAMP and zinc
Y Koh, HN Kim, JJ Hwang, YH Kim, SE Park
Molecular Brain 12, 1-11
Identifying new AMP-activated protein kinase inhibitors that protect against ischemic brain injury
JW Eom, TY Kim, BR Seo, H Park, JY Koh, YH
Kim
ACS Chemical Neuroscience 10 (5), 2345-2354
AMP-activated protein kinase contributes to zinc-induced neuronal death via activation by LKB1 and induction of Bim in mouse cortical cultures
JW Eom, JM Lee, JY Koh, YH Kim
Molecular
Brain 9, 1-13
Zinc preconditioning protects against neuronal apoptosis through the mitogen-activated protein kinase-mediated induction of heat shock protein 70
JM Lee, JM Lee, KR Kim, H Im, YH Kim
Biochemical and biophysical research communications 459 (2), 220-226
Poly (ADP-ribosyl) ation of p53 contributes to TPEN-induced neuronal apoptosis
HL Kim, H Ra, KR Kim, JM Lee, H Im, YH Kim
Molecules and cells 38 (4), 312-317
Consensus scoring approach to identify the inhibitors of AMP-activated protein kinase α2 with virtual screening
H Park, JW Eom, YH Kim
Journal of
chemical information and modeling 54 (7), 2139-2146
Zinc-triggered induction of tissue plasminogen activator and plasminogen in endothelial cells and pericytes
MK Cho, ES Sun, YH Kim
Experimental
Neurobiology 22 (4), 315
Zinc-triggered induction of tissue plasminogen activator by brain-derived neurotrophic factor and metalloproteinases
IY Hwang, ES Sun, JH An, H Im, SH Lee, JY
Lee, PL Han, JY Koh, YH Kim
Journal of neurochemistry 118 (5), 855-863
Essential role of p53 in TPEN-induced neuronal apoptosis
Essential role of p53 in TPEN-induced neuronal apoptosis
H Ra, HL Kim, HW Lee, YH Kim
FEBS letters 583 (9), 1516-1520
Essential role for zinc-triggered p75NTR activation in preconditioning
JY Lee, YJ Kim, TY Kim, JY Koh, YH Kim
Journal of Neuroscience 28 (43), 10919-10927
The involvement of caspase-11 in TPEN-induced apoptosis
JM Lee, YJ Kim, H Ra, SJ Kang, SJ Han, JY
Koh, YH Kim
FEBS letters 582 (13), 1871-1876
Non-proteolytic neurotrophic effects of tissue plasminogen activator on cultured mouse cerebrocortical neurons.
Kim YH, Koh JY
Exp Neurol 177(2):
407-418.
Title of the Research Publication
Author A, Author B, et al. Journal Name. Volume(Issue): Pages.
The role of NADPH oxidase and neuronal nitric oxide synthase in zinc-induced poly(ADP-ribose) polymerase activation and cell death in cortical culture.
Lee HY, Hwang IY, Im H, Koh JY, Kim YH
Neurochem 101: 1236-1247.
Non-proteolytic neuroprotection by human recombinant tissue plasminogen activator.
Kim YH, Park JH, Hong SH, Koh JY
Science, 284: 647-650.